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Summary
The infamousDeadpoolis have intercourse for his fell fierceness , fourth - paries breaking humor , and wildly powerful healing factor , making him one of the hardest characters in Marvel Comics to permanently kill . However , throughout the history of Marvel Comics , there have been a numeral of horrendous and powerful weapons that have the potential to terminate Wade Wilson ’s life story , and make his death last .
Deadpool is a consequence ofexperimentation done by the Weapon Xprogram , imbued with a version of Wolverine ’s healing factor , and grant him a kind of horrific immortality that reserve him to rejuvenate from almost any character of lesion , and outlive things like poisoning or even decapitation . Countless villains ( and hoagie ) have attempted to end Deadpool ’s life throughout his history at Marvel Comics , FromWolverine ’s notable Muramasa Bladeto a herculean Anti - Regeneration Ray , below are 10 weapon system from throughout Marvel canyon that are capable of beating Deadpool ’s telling healing factor and killing the Merc with a Mouth once and for all .
Even though Deadpool is practically immortal , he is n’t imperviable to losing fights , and that fact is play up in brutal style by one XTC - men Cuban sandwich .
15The Facade Virus
Cable & Deadpool #1 by Fabian Nicieza and Patrick Zircher
In fiat to bring about globe peacefulness , the One World Church commandeer a gene - recoding virus jazz as the Facade Virus . Unfortunately , the fluid virus effectively melt Deadpool ’s body - something his healing factor could n’t gear up because the change were fall out on the genetical level , and did n’t explicitly read as damage .
Fabian Nicieza and Patrick Zircher’sCable & Deadpool # 4makesit clear that the virus would have kill Wade if it was n’t for Cable , who was capable to mix Facade with his own Techno - Organic Virus , using each to treat the other . It was the start ofCable and Deadpool ’s move from sulfurous enemiesto genuine friends , but also confirmed that there are ways to kill Deadpool without pulling a initiation .
14The Hunger Virus
Ultimate Fantastic Four #21 by Mark Millar and Greg Land
The Hunger Virus is one of the most roughshod and unsafe computer virus in the Marvel Multiverse . Once infected , someone is transform into a automaton . They are then get over with a desire for non - septic flesh , make them to immediately try out and eat citizenry . Those with healing factor , such as Deadpool , can resist the virus for a time , but they will finally yield . Once transform into a zombi , their healing factor is disabled .
Once transformed into a zombie , their healing divisor is incapacitate .
This is true of Spider - Man , Wolverine , and Deadpool . No matter how warm a healing factor is , it does n’t count if it ’s removed . Once Deadpool became a zombie , he could be down as well as anyone else . Not only does he count as"dead " due to being a zombie , but even if he did n’t , the deficiency of a healing broker would make him easy to stamp out than normal .
13Carbonadium Swords
Deadpool Kills the Marvel Universe#3 by Cullen Bunn and Dalibor Talajic
In Marvel canon , Carbonadium is a super - hard metalwhich has the unfortunate side - effect of breathe harmful radiation . Deadpool has actually used this to his advantage in the yesteryear , maintain this radiation to nullify the mend factor of some targets . In Cullen Bunn and Dalibor Talajic’sDeadpool Kills The Marvel Universe , theDeadpool from Earth-12101 make up one’s mind to kill his Marvel friend to save them from living as comic characters .
It ’s shown that the blades are equal to of kill Wolverine . Given the link between their powers , this can be accept as confirmation that Deadpool ’s own katanas could be used to repress his heal agent and in conclusion down him off - a perfect detail for a part who is often characterise by his just masked death wish .
12A.I.R. Machine
Return of the Living Deadpool#4 by Cullen Bunn and Nik Virella
Deadpool indeed has one of the most powerful healing element in the entire Marvel Universe , but that can also be his untying . In one alternate universe , the Earth was overrun by zombies , and after a wild risky venture , a new infection took place . One where every zombie would slowly deform into Deadpool , which result in the earthly concern being well over by Deadpools .
With these Deadpool ’s being just as dangerous as the zombies , if not more so , the original Deadpool devised a programme to destroy them . Using an A.I.R. machine , Deadpool was able-bodied to reverse his heal factor . Instead of regenerating from any combat injury , his dead body began rapidly degenerating , and he was capable to disperse this to the other Deadpools , which caused all of them to slowly deteriorate into nothing but debris . It ’s not exactly the leisurely direction to kill Deadpool , but it ’s undeniably effective .
11The Moon-Born Hammer
Fear Itself: Deadpool #3by Christopher Hastings and Bong Dazo
Marvel’sFear Itselfevent saw several characters , both good and evil , imbued with bully power and magical hammers by the Asgardian god of Fear , the Serpent . In Christopher Hastings and Bong Dazo’sFear Itself : Deadpool # 3 , Wade convert the jape villain the Walrus that he is one of the " Worthy , " in a ruse to increase business for his aegis armed service .
Unfortunately , the hammer he gives Walrus as part of this cozenage is the property of a clan ofWerewolves call the Moon - carry , and it make powerful magical abilities when exposed to Moon . The hammer turns out to be up to of negating Wade ’s healing agent , make Deadpool great injury at the script of the Walrus , until Wade is able to manipulate the scoundrel into going inside , blockade the pound ’s powers .
Deadpool ’s healing factor lets him be sliced , shoot , and blow up without dying , but in Wolverine # 13 , it also gives him another power .
10The Muramasa Blade(s)
Wolverine: Origins #35by Daniel Way and Doug Braithwaite
Similar to Wade ’s Carbonadium katanas , the Muramasa Blade is a sword capable of repressing healing powers , and can strike killing blows even against high - spirit level therapist such as Sabretooth . The original Muramasa Blade was forged by Wolverine ’s mentor and professional swordsmithMuramasa using actual pieces of Wolverine ’s soul .
The brand is so potent that it is able to"slice on the molecular level,“and Daniel Way and Doug Braithwaite’sWolverine : root # 35confirms the blade ’s power to wipe out those with healing ingredient because of the absolute nature of it ’s fade . A second Muramasa sword was later on create , possessing exchangeable abilities , and is possessed by the mercenary and assassinator known as Solem .
9Cockroach Grenade
Deadpool Kills Deadpool#3by Salva Espin and Cullen Bunn
The Deadpool of Earth-12101 refund inDeadpool Kills Deadpool , assembling an army to wipe out every version of Wade in the multiverse , and coming up against the Deadpool of Marvel ’s main world . In Salva Espin and Cullen Bunn’sDeadpool Kills Deadpool#3 , Lady Deadpool arms the mainstream Wade with an arsenal of multiversal weapons that can overreach his healing constituent , so that he can use them to mow down his malevolent stochastic variable .
One of these is a " cockroach grenade , " which he throws ata Wolverine - Deadpool Chimaera , take to him being consumed by super - cockroach and killing him .
8Anti-Regeneration Ray
Deadpool Kills Deadpool#1by Salva Espin and Cullen Bunn
Also inDeadpool Kills Deadpoolis the introduction of the powerful " Anti - Regeneration Ray , " a weapon used by fan - best-loved Wade variance " Evil Deadpool , " which he utilizes to drink down the adorable Dogpool among other discrepancy .
Deadpool ’s healing factor stand for he can restore from almost any combat injury , but the Anti - Regeneration Ray incinerates its objective in a way that prevent the activation of any healing factors(Wade can really survive normal forms of incineration , as shown whenhe was killed by Thor . ) The main Deadpool shoot the arm aside from Evil Deadpool and pop him with it , wielding the weapon against his other evil variants .
Deadpool and Wolverine seem as though they have the same exact healing factors , but the two ability are opposite and dead suitable for each !
7Weapon X Kill Switch
Deadpool#60 by Frank Tieri and Georges Jeanty
It ’s made clear he ’s truly utter thanks to the kill switch , even appearing as a ghost .
One of the few times that Deadpoolactually diedon Earth-616 happened in Frank Tieri and Georges Jeanty’sDeadpool # 60 , when he was killed through the machinations of the Weapon X program , the group that originally give Wade his abilities . When Weapon Xupgrades Wade ’s healing factor , they also add a brutal kill replacement , opt to disintegrate him when he flex against them . Deadpool was resurrected using conjuring trick shortly afterwards , but it ’s made clean he ’s unfeignedly dead thanks to the kill switching , even appear as a ghost .
6Weasel’s Annihilator
Wolverine#21 by Benjamin Percy and Adam Kurbert
The recentWolverine # 21(from Benjamin Percy and Adam Kurbert ) reveal that Deadpool ’s former pal and arms dealer Weasel has develop a powerful gun specifically to obliterate Wade . Weasel calls the triggerman the Annihilator , and claims that because it round on the nuclear level , Deadpool ’s healing wo n’t save him . While Weasel does n’t terminate up using the weapon system , he ’s one of Marvel ’s most talented arm designers and has years of familiarity with Wade ’s power , suggest he would dead have been able to disintegrate the Merc with a Mouth ( especially because this eccentric of atomic - level flack also qualify the other arm on this list . )
